The 1H, 15N, and 13C resonance assignments of the N-terminal domain of the nucleocapsid protein from the Middle East respiratory syndrome coronavirus.
Talita Stelling de AraujoGlauce Moreno BarbosaKaroline SanchesJéssica M AzevedoKatia Maria Dos Santos CabralMarcius S AlmeidaFabio Ceneviva Lacerda de AlmeidaPublished in: Biomolecular NMR assignments (2021)
During the past 17 years, the coronaviruses have become a global public emergency, with the first appearance in 2012 in Saudi Arabia of the Middle East respiratory syndrome. Among the structural proteins encoded in the viral genome, the nucleocapsid protein is the most abundant in infected cells. It is a multifunctional phosphoprotein involved in the capsid formation, in the modulation and regulation of the viral life cycle. The N-terminal domain of N protein specifically interacts with transcriptional regulatory sequence (TRS) and is involved in the discontinuous transcription through the melting activity of double-stranded TRS (dsTRS).
Keyphrases
- respiratory syndrome coronavirus
- sars cov
- binding protein
- transcription factor
- amino acid
- life cycle
- protein protein
- healthcare
- induced apoptosis
- public health
- mental health
- gene expression
- drug delivery
- oxidative stress
- cancer therapy
- genome wide
- small molecule
- signaling pathway
- mass spectrometry
- case report
- endoplasmic reticulum stress
- cell death