Distinct Myeloid Derived Suppressor Cell Populations Promote Tumor Aggression in Glioblastoma.

Christina JacksonChristopher CherrySadhana BomArbor G DykemaElizabeth A ThompsonMing ZhengZhicheng JiWenpin HouRunzhe LiHao ZhangJohn ChoiFausto RodriguezJon WeingartSrinivasan YegnasubramanianMichael LimChetan BettegowdaJonathan PowellJennifer EliesseffHongkai JiDrew Pardoll

Published in: bioRxiv : the preprint server for biology (2023)

Aggressive glioblastoma harbors two unique myeloid populations capable of promoting stem-like properties of tumor cells and suppressing T cell function in the tumor microenvironment.

Keyphrases

single cell
cell therapy
bone marrow
dendritic cells
genetic diversity
acute myeloid leukemia
signaling pathway