Inflammation and blood-brain barrier breach remote from the primary injury following neurotrauma.
Nicole M SmithMarcus K GiacciAlexander GoughCharlotte BaileyTerence McGonigleAnna M B BlackThomas O ClarkeCarole A BartlettK Swaminathan IyerSarah A DunlopMelinda FitzgeraldPublished in: Journal of neuroinflammation (2018)
Partial injury to the optic nerve induces a complex remote inflammatory response, characterized by rapidly increased pro- and anti-inflammatory cytokines in brain homogenates, increased numbers of IBA1+ cells throughout the visual pathways, and increased CD11b+ and ED1+ inflammatory cells, particularly towards the synaptic terminals. BBB permeability can increase prior to inflammatory cell infiltration, dependent on the brain region.
Keyphrases
- blood brain barrier
- induced apoptosis
- inflammatory response
- oxidative stress
- cerebral ischemia
- optic nerve
- cell cycle arrest
- emergency department
- white matter
- resting state
- single cell
- endoplasmic reticulum stress
- optical coherence tomography
- cell therapy
- cell proliferation
- multiple sclerosis
- brain injury
- prefrontal cortex