Baseline and post-treatment biomarkers of resistance to anti-PD-1 therapy in acral and mucosal melanoma: an observational study.

Irene M ShuiXiao Qiao LiuQing ZhaoSeung Tae KimYuan SunJennifer H YearleyTasmiah ChoudhuryAndrea L WebberClemens KreplerRazvan CristescuJeeyun Lee

Published in: Journal for immunotherapy of cancer (2022)

GEP and PD-L1 expression, TMB, immune cell infiltration, and RAS and WNT signaling warrant further investigation as potential mechanisms and/or biomarkers of anti-PD-1 therapy resistance in acral and mucosal melanomas. Confirmation of these findings in larger populations is needed.

Keyphrases

stem cells
risk assessment
cell therapy
replacement therapy
bone marrow
climate change