Chloroxine inhibits pancreatic cancer progression through targeted antagonization of the PI3K/AKT/mTOR signaling pathway.

Miaomiao LinYanyi XiaoYile DaiYefan MaoLiming XuQiyu Zhang Zhe Chen

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2023)

Chloroxine targeted and inhibited the PI3K-AKT-mTOR cascade to repress PCCs growth, migration, as well as invasion, and triggered cellular apoptosis. Therefore, chloroxine may constitute a potential antineoplastic drug for the treatment of pancreatic cancer.

Keyphrases

signaling pathway
cancer therapy
oxidative stress
pi k akt
endoplasmic reticulum stress
cell cycle arrest
cell migration
induced apoptosis
risk assessment
drug delivery
combination therapy
human health
climate change