Multiple long-term conditions in people with psoriasis: a latent class and bidirectional Mendelian randomisation analysis.

Five distinct clusters of psoriasis co-morbidities were observed with these findings to offer opportunities for an integrated approach to comorbidity prevention and treatment. Co-existing LTC share with psoriasis common genetic and non-genetic risk factors, and aggressive lifestyle modification in these people is anticipated to have an impact beyond psoriasis risk. Genetically predicted coronary artery disease is possibly associated with an increased risk of psoriasis, altering our prior knowledge.