Recipient ADAMTS13 Single-Nucleotide Polymorphism Predicts Relapse after Unrelated Bone Marrow Transplantation for Hematologic Malignancy.
Haruka NomotoAkiyoshi TakamiJ Luis EspinozaMakoto OnizukaKoichi KashiwaseYasuo MorishimaTakahiro FukudaYoshihisa KoderaNoriko DokiKoichi MiyamuraTakehiko MoriShinji NakaoEriko MorishitaPublished in: International journal of molecular sciences (2019)
Relapse remains a major obstacle to the survival of patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation. A disintegrin-like and metalloprotease with a thrombospondin type 1 motif (ADMATS13), which cleaves von Willebrand factor multimers into less active fragments, is encoded by the ADAMTS13 gene and has a functional single-nucleotide polymorphism (SNP) rs2285489 (C > T). We retrospectively examined whether ADAMTS13 rs2285489 affected the transplant outcomes in a cohort of 281 patients who underwent unrelated human leukocyte antigen (HLA)-matched bone marrow transplantation for hematologic malignancies. The recipient ADAMTS13 C/C genotype, which putatively has low inducibility, was associated with an increased relapse rate (hazard ratio [HR], 3.12; 95% confidence interval [CI], 1.25⁻7.77; P = 0.015), resulting in a lower disease-free survival rate in the patients with a recipient C/C genotype (HR, 1.64; 95% CI, 1.01⁻2.67; P = 0.045). Therefore, ADAMTS13 rs2285489 genotyping in transplant recipients may be a useful tool for evaluating pretransplantation risks.
Keyphrases
- free survival
- bone marrow
- allogeneic hematopoietic stem cell transplantation
- genome wide
- mesenchymal stem cells
- end stage renal disease
- endothelial cells
- acute lymphoblastic leukemia
- chronic kidney disease
- newly diagnosed
- acute myeloid leukemia
- cell therapy
- prognostic factors
- cord blood
- type diabetes
- copy number
- gene expression
- climate change
- stem cells
- insulin resistance
- human health
- induced pluripotent stem cells
- weight loss
- adipose tissue
- risk assessment
- transcription factor