miR-144-3p/miR-451a promotes lymphovascular invasion through repression of PTEN/p19 in rectal neuroendocrine tumors.

Noriaki MurayamaKoichi OkamotoTadahiko NakagawaJinsei MiyoshiKensei NishidaTomoyuki KawaguchiKaizo KagemotoShinji KitamuraBeibei MaHiroshi MiyamotoNaoki MugurumaMitsuyasu YanoKoichi TsuneyamaTakahiro FujimoriYasushi SatoTetsuji Takayama

Published in: Journal of gastroenterology and hepatology (2022)

Our data suggest that overexpression of miR-144/miR-451 cluster promotes LVI via repression of PTEN and p19 in rectal NET-G1 cells. miR-144/451 cluster may be a novel biomarker for predicting invasion/metastasis in rectal NET-G1.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
pi k akt
neuroendocrine tumors
rectal cancer
induced apoptosis
cell cycle arrest
squamous cell carcinoma
machine learning
signaling pathway
big data
endoplasmic reticulum stress