Bone marrow activation in response to metabolic syndrome and early atherosclerosis.
Ana DevesaManuel Lobo-GonzálezJuan Martínez-MillaBelén OlivaInes Garcia-LunarAnnalaura MastrangeloSamuel EspañaJavier SanzJosé M MendigurenHector BuenoJose Javier FusterVicente AndrésAntonio Fernández-OrtizDavid SanchoLeticia Fernández-FrieraJavier Sanchez-GonzalezXavier RosselloFrancesco LavarraValentin FusterPublished in: European heart journal (2022)
In apparently healthy individuals, BM 18F-FDG uptake is associated with MetS and its components, even in the absence of systemic inflammation, and with elevated counts of circulating leucocytes. Bone marrow activation is associated with early atherosclerosis, characterized by high arterial metabolic activity. Bone marrow activation appears to be an early phenomenon in atherosclerosis development.[Progression of Early Subclinical Atherosclerosis (PESA); NCT01410318].