Distinctive in vitro signal transduction profile of NLX-112, a potent and efficacious serotonin 5-HT1A receptor agonist.

Adrian Newman-TancrediJean-Claude MartelCristina CosiPeter HeuslerFabrice LestienneMark A VarneyDidier Cussac

Published in: The Journal of pharmacy and pharmacology (2017)

Unlike reference compounds, NLX-112 was a highly efficacious agonist in vitro, preferentially activating pERK in cell lines and Gαo proteins in rat hippocampal membranes. However, Gα subunit mRNA levels differ markedly between rat brain and cell lines, warranting caution when extrapolating from recombinant systems to native tissues.

Keyphrases

gene expression
signaling pathway
oxidative stress
binding protein
anti inflammatory
endoplasmic reticulum