A dithiacyclam-coordinated silver(i) polymer with anti-cancer stem cell activity.

Alice JohnsonLinda IfflandKuldip SinghUlf-Peter Apfel Kogularamanan Suntharalingam

Published in: Dalton transactions (Cambridge, England : 2003) (2021)

A cancer stem cell (CSC) active, solution stable, silver(i) polymeric complex bearing a dithiacyclam ligand is reported. The complex displays similar potency towards CSCs to salinomycin in monolayer and three-dimensional cultures. Mechanistic studies suggest CSC death results from cytosol entry, an increase in intracellular reactive oxygen species, and caspase-dependent apoptosis.

Keyphrases

cancer stem cells
reactive oxygen species
gold nanoparticles
cell death
silver nanoparticles
oxidative stress
endoplasmic reticulum stress
drug delivery
cell cycle arrest
induced apoptosis
drug release
case control
signaling pathway