Influenza A (H1N1) virus induced long-term remission in a refractory acute myeloid leukaemia.
Liang-Shun YouYi LiuNianci ChenLi ZhuGaixiang XuZuopo LvYile ZhouChenying LiHongyan TongJie JinHaitao MengPublished in: British journal of haematology (2023)
There have been reports of haematological cancer patients achieving spontaneous remission after being infected with the influenza A or SARS-COV-2 virus. Here, we present the first case of long-term complete remission (CR) induced by influenza A (IAV, H1N1 subtype) in a refractory AML patient and have functionally validated this finding in two different animal disease models. We observed a significant increase in the proportion of helper T cells in the patient after IAV infection. The levels of cytokines, including IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-γ and TNF-α, were higher in IAV-infected patients compared with control groups. These findings indicate that the anti-tumour effects induced by IAV are closely related to the modification of the immune response. Our study provides new evidence of the anti-tumour effects of IAV from a clinical practice perspective.
Keyphrases
- immune response
- sars cov
- dendritic cells
- clinical practice
- disease activity
- acute myeloid leukemia
- rheumatoid arthritis
- emergency department
- bone marrow
- ulcerative colitis
- drug induced
- liver failure
- intensive care unit
- hepatitis b virus
- oxidative stress
- toll like receptor
- regulatory t cells
- acute respiratory distress syndrome
- adverse drug