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Sustained Mood Improvement with Laughing Gas Exposure (SMILE): Study protocol for a randomized placebo-controlled pilot trial of nitrous oxide for treatment-resistant depression.

Karim S LadhaJiwon LeeGabriella F MattinaJanneth Pazmino-CanizaresDuminda Nalaka WijeysunderaFatemeh Gholamali NezhadKaylyssa PhilipVanessa K TassoneFathima AdamsahibVenkat Bhatnull null
Published in: PloS one (2024)
ClinicalTrials.gov NCT04957368. Registered on July 12, 2021.
Keyphrases
  • placebo controlled
  • sleep quality
  • double blind
  • bipolar disorder
  • depressive symptoms
  • room temperature
  • phase ii
  • study protocol
  • phase iii
  • phase ii study
  • clinical trial