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Risks and benefits of sentinel lymph node evaluation in the management of endometrial intraepithelial neoplasia.

Lauren M LimHadi ErfaniKatelyn B FureyKoji MatsuoX Mona Guo
Published in: Expert review of anticancer therapy (2024)
Sentinel lymph node evaluation for patients with EIN is safe, feasible, and particularly important for the approximately 10% of patients with high-risk endometrial carcinoma on final pathology. However, as most diagnosed carcinomas are low-risk, SLN evaluation would have limited oncologic benefit. While SLN assessment may overtreat most patients with EIN, a significant minority of patients will be improperly staged. We propose an algorithm highlighting the importance of maximal preoperative endometrial sampling and stratifying patients via risk factors to selectively identify those who would benefit most from SLN evaluation.
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