Therapeutic Targeting of Macrophage Plasticity Remodels the Tumor-Immune Microenvironment.

Hee-Jin Jang Hyun-Sung LeeWendong YuMaheshwari RamineniCynthia Y TruongDaniela RamosTaylor SplawnJong Min ChoiSung Yun JungJu-Seog LeeDaniel Y WangJoel M SederstromMassimo PietropaoloFarrah KheradmandChristopher Ian AmosThomas M WheelerR Taylor RipleyBryan M Burt

Published in: Cancer research (2022)

Comprehensive single-cell proteomics analyses of lung adenocarcinoma progression reveal the role of tumor-associated macrophages in resistance to PD-1 blockade therapy. See related commentary by Lee et al., p. 2515.

Keyphrases

single cell
rna seq
stem cells
mass spectrometry
high throughput
adipose tissue
cancer therapy
genome wide
gene expression
drug delivery
dna methylation