Characterization of a Novel Composite Staphylococcal Cassette Chromosome mec in Methicillin-Resistant Staphylococcus pseudintermedius from Thailand.

Pattrarat ChanchaithongNuvee PrapasarakulVincent PerretenSybille Schwendener

Published in: Antimicrobial agents and chemotherapy (2015)

A novel staphylococcal cassette chromosome mec (SCCmec) composite island (SCCmecAI16-SCCczrAI16-CI) was identified in Staphylococcus pseudintermedius. Four integration site sequences for SCC subdivided the 60,734-bp island into 41,232-bp SCCmecAI16, 19,400-bp SCCczrAI16, and 102-bp SCC-likeAI16 elements. SCCmecAI16 represents a new combination of ccrA1B3 genes with a class A mec complex. SCCczrAI16 contains ccrA1B6 and genes related to restriction modification and heavy metal resistance. SCCmecAI16-SCCczrAI16-CI was found in methicillin-resistant S. pseudintermedius sequence type 112 (ST112) and ST111 isolated from dogs and veterinarians in Thailand.

Keyphrases

staphylococcus aureus
biofilm formation
methicillin resistant staphylococcus aureus
heavy metals
genome wide
copy number
genome wide identification
risk assessment
gene expression
pseudomonas aeruginosa
genome wide analysis
transcription factor
candida albicans