Possible role of annexin A1/FPR2 pathway in COX2/NLRP3 inflammasome regulation in alveolar bone cells of estrogen-deficient female rats with diabetes mellitus.
Gisela Rodrigues da Silva SassoPaulo Sergio CerriEstela Sasso-CerriManuel de Jesus SimõesCristiane Damas GilRinaldo Florêncio-SilvaPublished in: Journal of periodontology (2023)
These results indicate a possible role for the ANXA1/FPR2 pathway as a fine-tuning/anti-inflammatory regulator to counterbalance exacerbated COX2/NLRP3/IL-1β activation in bone cells during bone remodeling under estrogen deficiency and DM.
Keyphrases
- nlrp inflammasome
- induced apoptosis
- bone mineral density
- cell cycle arrest
- anti inflammatory
- soft tissue
- bone loss
- endoplasmic reticulum stress
- estrogen receptor
- bone regeneration
- air pollution
- oxidative stress
- signaling pathway
- cell death
- transcription factor
- cell proliferation
- glycemic control
- body composition
- weight loss