Role of cAMP in Cardiomyocyte Viability: Beneficial or Detrimental?

Yishuai ZhangSi Chen Lingfeng LuoSarah GreenlyHangchuan ShiJasmine Jiayuan XuChen Yan

Published in: Circulation research (2023)

Our findings indicate that the functional diversity of different GsPCRs in cardiomyocyte viability could be achieved by their ability to form unique signaling complexes (signalosomes) that determine the fate of cAMP: either stimulate ATP release by activating PKA or directly efflux to be e[cAMP].

Keyphrases

binding protein
angiotensin ii
protein kinase
signaling pathway
high glucose