Immune checkpoint inhibition in patients treated with stereotactic radiation for brain metastases.

Emily S KowalskiJill S RemickKai SunGregory S AlexanderRahul KhairnarEmily MorseHua-Ren CherngLars J BergYannick PoirierNarottam LamichhaneStewart BeckerShifeng ChenJason K MolitorisYoung KwokWilliam F RegineMark V Mishra

Published in: Radiation oncology (London, England) (2020)

These results suggest SRT-ICI may improve local control of brain metastases and is not associated with an increased risk of symptomatic radiation necrosis in a cohort of predominantly NSCLC patients. Larger, prospective studies are necessary to validate these findings and better elucidate the impact of SRT-ICI on other disease outcomes.

Keyphrases

brain metastases
small cell lung cancer
end stage renal disease
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
metabolic syndrome
radiation induced
type diabetes
adipose tissue
advanced non small cell lung cancer