Physical Frailty and Brain White Matter Abnormalities: The ARIC Study.
Emma L DuccaGabriela T GomezPriya PaltaKevin J SullivanClifford R JackDavid S KnopmanRebecca F GottesmanJeremy WalstonB Gwen WindhamKeenan A WalkerPublished in: The journals of gerontology. Series A, Biological sciences and medical sciences (2022)
The current study demonstrates a robust association of WMH volume with current and future frailty. Although measures of white matter microstructure were altered in frail individuals, these measures were not generally associated with progression from non-frail to frail status.