De Novo Design of Selective Quadruplex-Duplex Junction Ligands and Structural Characterisation of Their Binding Mode: Targeting the G4 Hot-Spot.

Laura Díaz-CasadoIsrael Serrano-ChacónLaura Montalvillo-JiménezFrancisco CorzanaÁgatha Bastida Andrés G SantanaCarlos GonzálezJuan Luis Asensio

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2021)

Invited for the cover of this issue are Andrés G. Santana, Carlos González, Juan Luis Asensio and co-workers at Instituto de Química Orgánica General, Instituto de Química-Física Rocasolano and Universidad de La Rioja. The image depicts drug selectivity using a metaphor of an arrow hitting a target. Read the full text of the article at 10.1002/chem.202005026.

Keyphrases

deep learning
cancer therapy
single molecule
smoking cessation
dna binding
binding protein
drug induced
drug delivery
machine learning