TGFβ signalling: a nexus between inflammation, placental health and preeclampsia throughout pregnancy.
Monika Horvat MercnikCarolin SchliefsteinerGonzalo Sánchez-DuffhuesChristian WadsackPublished in: Human reproduction update (2024)
The dysregulation of TGFβ signalling in PE has important implications for research and clinical practice. Further investigation is required to understand the underlying mechanisms, including the role of different ligands and their regulation under pathophysiological conditions, in order to discover new therapeutic targets. Distinguishing between clinically manifested subtypes of PE and studying TGFβ signalling in different placental cell types holistically is an important first step. To put this knowledge into practice, pre-clinical animal models combined with new technologies are needed. This may also lead to improved human research models and identify potential therapeutic targets, ultimately improving outcomes for affected pregnancies and reducing the burden of PE.
Keyphrases
- transforming growth factor
- healthcare
- clinical practice
- pregnancy outcomes
- preterm birth
- endothelial cells
- public health
- oxidative stress
- epithelial mesenchymal transition
- primary care
- early onset
- mental health
- human health
- stem cells
- pregnant women
- risk assessment
- risk factors
- quality improvement
- induced pluripotent stem cells
- skeletal muscle
- climate change
- bone marrow
- gestational age