Distribution of mucosal PD-1 expressing T cells in patients with colitis of different etiologies.
Britt RoosenboomCarmen S Horjus Talabur HorjeCarolijn SmidsJan Willem LeeuwisElly van KoolwijkMarcel J M GroenenPeter J WahabEllen G van LochemPublished in: Scandinavian journal of gastroenterology (2021)
There are relevant differences in distribution and frequencies of mucosal PD-1+ T-cell subsets in patients with UC, CD, InfC and ImC, supporting the hypothesis that these types of colitis are driven by different immunological pathways. The increased numbers of PD-1+ and PD-L1+ lymphocytes in the colonic mucosa of UC patients suggest that the PD-1/PD-L1 pathway might be more activated in UC than in CD.