Login / Signup

Iodide-Selective Synthetic Ion Channels Based on Shape-Persistent Organic Cages.

Bahiru Punja BenkePulakesh AichYounghoon KimKyung Lock KimMd Rumum RohmanSoonsang HongIn-Chul HwangEun Hui LeeJoon Ho RohKimoon Kim
Published in: Journal of the American Chemical Society (2017)
We report here a synthetic ion channel developed from a shape-persistent porphyrin-based covalent organic cage. The cage was synthesized by employing a synthetically economical dynamic covalent chemistry (DCC) approach. The organic cage selectively transports biologically relevant iodide ions over other inorganic anions by a dehydration-driven, channel mechanism as evidenced by vesicle-based fluorescence assays and planar lipid bilayer-based single channel recordings. Furthermore, the organic cage appears to facilitate iodide transport across the membrane of a living cell, suggesting that the cage could be useful as a biological tool that may replace defective iodide channels in living systems.
Keyphrases
  • water soluble
  • high throughput
  • ionic liquid
  • cell therapy
  • bone marrow
  • single molecule
  • metal organic framework