Development of IL-15/IL-15Rα sushi domain-IgG4 Fc complexes in Pichia pastoris with potent activities and prolonged half-lives.
Huan XuMingyang ShiChangsheng ShaoHao LiJing WuYin YuFang FangYugang GuoWeihua XiaoPublished in: Microbial cell factories (2021)
These findings indicate that the IL-15/SuIL-15Rα-dFc and IL-15/SuIL-15Rα-mFc produced in P. pastoris exhibit potent activities and prolonged half-lives and may serve as superagonists for immunotherapy in further research and applications.
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