Particulate matter from car exhaust alters function of human iPSC-derived microglia.

Henna JänttiSteffi JonkMireia Gómez BudiaSohvi OhtonenIlkka FagerlundMohammad Feroze FazaludeenPäivi Aakko-SaksaAlice PebayŠárka LehtonenJari KoistinahoKatja M KanninenPasi I JalavaTarja MalmPaula Korhonen

Published in: Particle and fibre toxicology (2024)

Our study indicates that traffic-related air pollutants alter the function of human microglia and warrant further studies to determine whether these changes contribute to adverse effects in the brain and on cognition over time. This study demonstrates human iPSC-microglia as a valuable tool to study functional microglial responses to environmental agents.

Keyphrases

endothelial cells
particulate matter
induced pluripotent stem cells
neuropathic pain
white matter
brain injury
lps induced
resting state
subarachnoid hemorrhage
cerebral ischemia
drug induced