Lithium improved behavioral and epileptic symptoms in an adolescent with ring chromosome 20 and bipolar disorder not otherwise specified.

Adlane InalBoris ChaumetteMaryam SoleimaniAnne-Marie GuerrotAlice GoldenbergAxel LebasPriscille GerardinVladimir Ferrafiat

Published in: Clinical case reports (2018)

We present a case of ring chromosome 20 syndrome in a twelve-year-old girl, with resistant epileptic disease and severe behavioral impairment that both drastically improved after a lithium challenge. If replicated, this could support the use of lithium as a safe treatment in the management of this severe phenotype.

Keyphrases

bipolar disorder
solid state
early onset
copy number
young adults
major depressive disorder
mental health
drug induced
gene expression
depressive symptoms
physical activity
combination therapy
smoking cessation