Effect of COVID-19 medications on corrected QT interval and induction of torsade de pointes: Results of a multicenter national survey.

Hamidreza FallahReza GolipraJalal KheirkhahAllahyar GolabchiJavad ShahabiSaeed Oni-HerisRamin SamiMarzieh TajmirriahiMehrdad SaraviMozhdeh KhatamiMehran VarnasseriMohammadreza KiarsiSeyed Fakhreddin HejaziMojtaba Yousefzadeh RahaghiMaryam TaherkhaniHaleh AshrafMohammad Sadegh KeshmiriMohammad Ali AkbarzadehAli BozorgiFateme MottaghizadehBehnam HedayatMona HeidaraliAzita Hajhossein Talasaz

Published in: International journal of clinical practice (2021)

This cohort showed significant QTc prolongation with all COVID-19 medications studied, however, life-threatening arrhythmia of TdP occurred rarely. Among the repurposed drugs studied, hydroxychloroquine or lopinavir-ritonavir alone or in combination with azithromycin clearly demonstrated to increase the risk of critical QT prolongation and/or TdP.

Keyphrases

drug induced
coronavirus disease
sars cov
amyotrophic lateral sclerosis
respiratory syndrome coronavirus
antiretroviral therapy