Suppressor of cytokine signalling 3 (SOCS3) expressed in podocytes attenuates glomerulonephritis and suppresses autoantibody production in an imiquimod-induced lupus model.

Masashi FukutaKotaro SuzukiShotaro KojimaYoko YabeKazumasa SuzukiKazuma IidaHiroyuki YamadaShinichi MakinoArifumi IwataShigeru TanakaTaro IwamotoAkira SutoDaiki NakagomiHidefumi WakashinYuko MaezawaYoshiro MaezawaMinoru TakemotoKatsuhiko AsanumaHiroshi Nakajima

Published in: Lupus science & medicine (2021)

SOCS3 expressed in podocytes plays protective roles for the development of glomerulonephritis and inhibits autoantibody production in the imiquimod-induced lupus model presumably by suppressing IL-6 production of podocytes.

Keyphrases

high glucose
endothelial cells
systemic lupus erythematosus
diabetic rats
disease activity
diabetic nephropathy
drug induced
oxidative stress
rheumatoid arthritis