Genetic Characterization and Prognostic Relevance of Acquired Uniparental Disomies in Cytogenetically Normal Acute Myeloid Leukemia.

Christopher J WalkerJessica KohlschmidtAnn-Kathrin EisfeldKrzysztof MrózekSandya LiyanarachchiChi SongDeedra NicoletJames S BlachlyMarius BillDimitrios PapaioannouChristopher C OakesBrian GiacopelliLuke K GenutisSophia E MaharryShelley OrwickKellie J ArcherBayard L PowellJonathan E KolitzGeoffrey L UyEunice S WangAndrew J CarrollRichard M StoneJohn C ByrdAlbert de la ChapelleClara D Bloomfield

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

LOH mediated by UPD is a recurrent feature of CN-AML. Detection of UPDs of 13q and 11p might be useful for genetic risk stratification of patients with CN-AML.

Keyphrases

acute myeloid leukemia
lymph node metastasis
allogeneic hematopoietic stem cell transplantation
machine learning
genome wide
loop mediated isothermal amplification
deep learning
real time pcr
copy number
gene expression
dna methylation
neural network
sensitive detection