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Rethinking intercurrent events in defining estimands for tuberculosis trials.

Tra My PhamConor D TweedJames R CarpenterBrennan C KahanAndrew J NunnAngela M CrookHanif EsmailRuth GoodallPatrick Peter John PhillipsIan R White
Published in: Clinical trials (London, England) (2022)
The estimand framework clarifies many issues in tuberculosis trials but also challenges trialists to justify and improve their outcome definitions. Future trialists should consider all the above points in defining their outcomes.
Keyphrases
  • mycobacterium tuberculosis
  • pulmonary tuberculosis
  • hiv aids
  • adverse drug
  • emergency department
  • hepatitis c virus
  • human immunodeficiency virus
  • hiv infected