Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2.
Konrad FischerBeate RieblingerRabea HeinRiccardo SfrisoJulia ZuberAndrea FischerBernhard KlingerWei LiangKrzysztof FlisikowskiMayuko KuromeValeri ZakhartchenkoBarbara KesslerEckhard WolfRobert RiebenReinhard SchwinzerAlexander KindAngelika SchniekePublished in: Xenotransplantation (2019)
We showed that pigs carrying several xenoprotective transgenes and knockouts of xenoreactive antigens can be readily generated and these modifications will have significant effects on xenograft survival.