NOTUM-MEDIATED WNT SILENCING DRIVES EXTRAVILLOUS TROPHOBLAST CELL LINEAGE DEVELOPMENT.

) cells play a critical role in transforming the uterine environment into a supportive organ facilitating embryonic/fetal development. Insufficient EVT cell-dependent uterine transformation can lead to obstetrical complications, including early pregnancy loss, preeclampsia, intrauterine growth restriction, and preterm birth. These complications carry a significant burden of morbidity and mortality for both the mother and the fetus. Notum, palmitoleoyl-protein carboxylesterase, a WNT signaling antagonist, is involved in promoting and maintaining EVT cell differentiation. This process is essential for the proper development of the placenta and is crucial for a healthy pregnancy.