IKKβ stabilizes Mitofusin 2 and suppresses doxorubicin cardiomyopathy.

Matthew GubermanRimpy DhingraJenna CrossVictoria MarguletsHongying GangInna Rabinovich-NikitinLorrie A Kirshenbaum

Published in: Cardiovascular research (2024)

The findings of this study reveal a novel survival pathway for IKKβ that is mutually dependent upon and obligatory linked to the phosphorylation and stabilization of the mitochondrial dynamics protein MFN2.

Keyphrases

oxidative stress
drug delivery
signaling pathway
cancer therapy
single cell
gene expression
protein protein
amino acid
free survival
binding protein
atrial fibrillation