SDCBP-AS1 destabilizes β-catenin by regulating ubiquitination and SUMOylation of hnRNP K to suppress gastric tumorigenicity and metastasis.
Jing HanMenglin NieCong ChenXiaojing ChengTing GuoLongtao HuangfuXiaomei LiHong DuXiaofang XingJiafu JiPublished in: Cancer communications (London, England) (2022)
SDCBP2-AS1 interacts with hnRNP K to suppress tumorigenesis and metastasis of GC and regulates post-transcriptional modifications of hnRNP K to destabilize β-catenin. These findings suggest SDCBP2-AS1 as a potential target for the treatment of GC.