Login / Signup

SDCBP-AS1 destabilizes β-catenin by regulating ubiquitination and SUMOylation of hnRNP K to suppress gastric tumorigenicity and metastasis.

Jing HanMenglin NieCong ChenXiaojing ChengTing GuoLongtao HuangfuXiaomei LiHong DuXiaofang XingJiafu Ji
Published in: Cancer communications (London, England) (2022)
SDCBP2-AS1 interacts with hnRNP K to suppress tumorigenesis and metastasis of GC and regulates post-transcriptional modifications of hnRNP K to destabilize β-catenin. These findings suggest SDCBP2-AS1 as a potential target for the treatment of GC.
Keyphrases
  • epithelial mesenchymal transition
  • cell proliferation
  • gene expression
  • transcription factor
  • binding protein
  • oxidative stress
  • mass spectrometry
  • signaling pathway
  • heat shock
  • heat stress
  • heat shock protein