Peripheral infusion of human umbilical cord mesenchymal stem cells rescues acute liver failure lethality in monkeys.

Gang GuoXiang ZhuangQing XuZhenru WuYongjie ZhuYongjie ZhouYuanmin LiYanrong LuBo ZhangPrue TalbotJiayu LiaoJunjun SheHong BuYu-Jun Shi

Published in: Stem cell research & therapy (2019)

Our study reveals the critical role of monocyte-derived IL-6 in initiating and accelerating acute liver failure and hUC-MSC treatment can disrupt the development of the inflammatory cascade by inhibiting monocyte activation. Early hUC-MSC treatment disrupts the development of the inflammatory cascade, indicating a potential clinical solution for acute liver failure.

Keyphrases

liver failure
mesenchymal stem cells
hepatitis b virus
umbilical cord
endothelial cells
dendritic cells
oxidative stress
low dose
stem cells
peripheral blood
combination therapy
induced pluripotent stem cells
extracorporeal membrane oxygenation