Aberrant resting-state functional connectivity underlies cognitive and functional impairments in remitted patients with bipolar disorder.

Lydia ForteaAlexander T Ysbaek-NielsenJulian MacoveanuJeff Zarp PetersenPatrick M FisherLars Vedel KessingGitte M KnudsenJoaquim RaduaEduard VietaKamilla W Miskowiak

Published in: Acta psychiatrica Scandinavica (2023)

Cognitive impairments in BD seem to be associated with a hyper-connectivity within the DMN, which may explain the failure to suppress task-irrelevant DMN activity during the cognitive performance, and blunted anticorrelation in the ECN. Thus, aberrant connectivity within the DMN and ECN may serve as brain targets for pro-cognitive interventions.

Keyphrases

resting state
functional connectivity
bipolar disorder
major depressive disorder
multiple sclerosis
white matter