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In silico design of the first DNA-independent mechanism-based inhibitor of mammalian DNA methyltransferase Dnmt1.

Vedran MiletićIvica OdorčićPatrik NikolićŽeljko M Svedružić
Published in: PloS one (2017)
Presented results can be used for preparation of some highly specific and potent inhibitors of mammalian DNA methylation with specific pharmacological properties.
Keyphrases
  • dna methylation
  • circulating tumor
  • cell free
  • single molecule
  • genome wide
  • gene expression
  • molecular docking
  • nucleic acid
  • mass spectrometry
  • copy number
  • simultaneous determination