A DNA origami nanostructure embedded with NQO1-activated prodrugs for precision drug delivery.
Zhimei HeWenjie XiangQin FanLian-Hui WangJie ChaoPublished in: Chemical communications (Cambridge, England) (2023)
A rectangle DNA origami nanostructure equipped with doxorubicin-derived prodrugs targeting a tumor cell-specific enzyme (NQO1) is constructed. Combining the high prodrug payload of DNA origami and NQO1-activated chemotherapy, this nanosystem presents therapeutic selectivity for NQO1-overexpressing MCF-7 cells over healthy L02 cells, offering a potent strategy for precision cancer therapy.
Keyphrases
- cancer therapy
- drug delivery
- induced apoptosis
- circulating tumor
- cell free
- single molecule
- cell cycle arrest
- endoplasmic reticulum stress
- nucleic acid
- signaling pathway
- squamous cell carcinoma
- wastewater treatment
- radiation therapy
- oxidative stress
- locally advanced
- breast cancer cells
- anti inflammatory
- bone marrow
- circulating tumor cells
- structural basis