Scoping review of rational polytherapy in patients with drug-resistant epilepsy.
McKenzie S GrinaldsCaleb YoderZach KraussAleda M H ChenDenise H RhoneyPublished in: Pharmacotherapy (2022)
Strengths of the evidence include addressing a variety of outcomes. Inconsistent definitions of DRE, small sample sizes, and heterogeneity among studies limit the ability to draw meaningful conclusions. Optimal combinations of ASMs for rational polytherapy for DRE is unclear.