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Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives.

Saloni KakkarSanjiv KumarSiong Meng LimKalavathy RamasamyVasudevan ManiSyed Adnan Ali ShahBalasubramanian Narasimhan
Published in: Chemistry Central journal (2018)
The performed antimicrobial activity indicated that compounds 3, 5, 6, 8 and 14 showed promising activity against selected microbial species. Antiproliferative screening found compound 14 to be the most potent compound against HCT116 (IC50 = 71.8 µM), whereas Compound 6 was the most potent against MCF7 (IC50 = 74.1 µM). Further, the molecular docking study has been carried to find out the interaction between active oxazole compounds with CDK8 (HCT116) and ER-α (MCF7) proteins indicated that compound 14 and 6 showed good dock score with better potency within the ATP binding pocket and may be used as a lead for rational drug designing of the anticancer molecule.
Keyphrases
  • molecular docking
  • breast cancer cells
  • microbial community
  • anti inflammatory
  • cell cycle
  • cell proliferation
  • cell cycle arrest
  • binding protein
  • estrogen receptor
  • drug induced