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Role of Src kinase in regulating protein kinase C mediated phosphorylation of TRPV1.

Gabriella L RobilottoDurga P MohapatraAndrew J ShepherdAaron D Mickle
Published in: European journal of pain (London, England) (2022)
Src kinase-mediated phosphorylation of TRPV1 is a critical regulator of the PKC-induced sensitization induced by multiple inflammatory mediators. This suggest a new regulatory mechanism governing TRPV1 function and a potential therapeutic target for inflammatory type pain, including cancer pain where Src antagonists are currently utilized.
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