Role of Src kinase in regulating protein kinase C mediated phosphorylation of TRPV1.
Gabriella L RobilottoDurga P MohapatraAndrew J ShepherdAaron D MicklePublished in: European journal of pain (London, England) (2022)
Src kinase-mediated phosphorylation of TRPV1 is a critical regulator of the PKC-induced sensitization induced by multiple inflammatory mediators. This suggest a new regulatory mechanism governing TRPV1 function and a potential therapeutic target for inflammatory type pain, including cancer pain where Src antagonists are currently utilized.
Keyphrases
- protein kinase
- neuropathic pain
- tyrosine kinase
- chronic pain
- spinal cord
- pain management
- spinal cord injury
- oxidative stress
- transcription factor
- papillary thyroid
- diabetic rats
- high glucose
- drug induced
- squamous cell
- squamous cell carcinoma
- risk assessment
- human health
- young adults
- endothelial cells
- climate change
- postoperative pain