Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations.

Jia WenMunan XieBryce RowlandJonathan D Rosen Quan SunJiawen ChenAmanda L TapiaHuijun QianMadeline H KowalskiYue ShanKristin L YoungMarielisa GraffMaria ArgosChristy L AveryStephanie A BienSteven BuyskeJie YinHelene ChoquetMyriam FornageChani J HodonskyEric JorgensonCharles KooperbergRuth J F LoosYongmei LiuJee-Young MoonKari E NorthStephen S RichJerome I RotterJennifer A Smith Wei ZhaoLulu ShangTao WangXiang ZhouAlexander P ReinerLaura M RaffieldYun Li

Published in: Genes (2021)

These analyses demonstrate the importance of performing TWAS and other genetic analyses across diverse populations and of balancing sample size and ancestry background matching when selecting a TWAS reference panel.

Keyphrases

genome wide
single cell
african american
rna seq
gene expression
cell therapy
genome wide association study
genetic diversity
copy number