Vitamin K2 immunosuppressive effect on pediatric patients with atopic dermatitis.

Wencheng XuKehan MengHongguang WuTaro MiuraShunsuke SuzukiMasako ChiyotandaSachiko TanakaKentaro Sugiyama Hisashi KawashimaToshihiko Hirano

Published in: Pediatrics international : official journal of the Japan Pediatric Society (2019)

Vitamin K2 -inhibited T-cell mitogen stimulated proliferation of PBMCs from pediatric AD patients in a dose-dependent manner. The PBMCs from pediatric AD patients were more sensitive to the immunosuppressive efficacy of vitamin K2 than the PBMCs from healthy subjects. The individual immunosuppressive pharmacological efficacy of vitamin K2 and of tacrolimus could be inferred from the blood eosinophil count of pediatric AD patients.

Keyphrases

atopic dermatitis
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
signaling pathway
inflammatory response
childhood cancer