Low Neuroactive Steroids Identifies a Biological Subtype of Depression in Adults with Human Immunodeficiency Virus on Suppressive Antiretroviral Therapy.

Shibani S MukerjiVikas MisraDavid R LorenzSukrutha ChettimadaKiana KellerScott LetendreRonald J EllisSusan MorgelloRobert A ParkerDana Gabuzda

Published in: The Journal of infectious diseases (2022)

These findings suggest that altered neuroactive steroid metabolism may contribute to the pathophysiological mechanisms of depression in ART-treated HIV-infected adults, representing a potential biological pathway for therapeutic targeting.

Keyphrases

antiretroviral therapy
human immunodeficiency virus
hiv infected
hiv positive
hiv infected patients
hiv aids
depressive symptoms
sleep quality
cancer therapy
risk assessment