CRY2 mediates the cognitive decline induced by sleep deprivation in 5xFAD mice.

Sumei LuoLizhe GuoNa ChenQulian GuoYongqiu XieYunjiao WangE Wang

Published in: PloS one (2024)

Our study demonstrated that sleep deprivation upregulated CRY2 in the hippocampus of AD mice, which resulted in synaptic dysfunction by decreasing CISH-mediated STAT1 phosphorylation.

Keyphrases

cognitive decline
mild cognitive impairment
high fat diet induced
physical activity
sleep quality
oxidative stress
cell proliferation
prefrontal cortex
cognitive impairment
type diabetes
metabolic syndrome
insulin resistance
depressive symptoms
protein kinase