Tumor protein D52 is upregulated in oral squamous carcinoma cells under hypoxia in a hypoxia-inducible-factor-independent manner and is involved in cell death resistance.

Yuzo AbeYoshiki MukudaiMai KuriharaAsami HouriJunichiro ChikudaAtsutoshi YasoKosuke KatoToshikazu ShimaneTatsuo Shirota

Published in: Cell & bioscience (2021)

This study showed that the expression of TPD52 increases in OSCC cells under hypoxia in a HIF-independent manner and plays an important role in the proliferation and survival of the cells in concordance with HIF, suggesting that novel cancer therapeutics might be led by TPD52 suppression.

Keyphrases

cell cycle arrest
cell death
induced apoptosis
endothelial cells
signaling pathway
endoplasmic reticulum stress
small molecule
squamous cell carcinoma
binding protein
oxidative stress
squamous cell
low grade
protein protein