Congenital heart defects in Arabian horses and the prospects of genetic testing: A review.
Caitlin BrownMonika StefaniukAnnelies DecloedtNiek BeijerinkNatasha A HamiltonBrandon D VeliePublished in: Equine veterinary journal (2024)
Congenital heart defects (CHDs) can have profound and potentially life-threatening consequences on horses' health and performance capability. While CHDs are rare in the general horse population, the Arabian breed is disproportionately overrepresented and thus is widely suspected to be genetically predisposed. This review discusses the most common CHDs in Arabian horses, including ventricular septal defect (VSD), tetralogy of Fallot (TOF), patent duct arteriosus (PDA), tricuspid valve atresia (TVA) and atrial septal defect (ASD). This review also explores how future research into the genetic factors that likely underpin many CHDs can revolutionise the way these disorders are managed in Arabian horses.
Keyphrases
- aortic valve
- mitral valve
- healthcare
- current status
- public health
- autism spectrum disorder
- mass spectrometry
- intellectual disability
- aortic stenosis
- ms ms
- mental health
- transcatheter aortic valve replacement
- genome wide
- pulmonary embolism
- catheter ablation
- attention deficit hyperactivity disorder
- left atrial
- gene expression
- dna methylation
- risk assessment
- ejection fraction