Hydroxychloroquine and Risk of Long QT Syndrome in Rheumatoid Arthritis: A Veterans Cohort Study with 19-Year Follow-up.

Mercedes E QuiñonesJoyce K JosephSharon DowellHans J MoorePamela E KarasikGregg C FonarowRoss D FletcherYan ChengQing Zeng-TreitlerCherinne ArundelAngelike P LiappisHelen M SheriffSijian ZhangDaniel D TaubMichael S HeimallCharles FaselisGail S KerrAli Ahmed

Published in: Arthritis care & research (2022)

Hydroxychloroquine use had no association with LQTS during the first 2 years after initiation of therapy. There was a higher risk thereafter which became significant after 5 years of therapy. However, the 5-year absolute risk was very low, and the absolute risk difference was even lower. Both risks attenuated during longer follow-up. These findings provide evidence for long-term safety of hydroxychloroquine in patients with RA.

Keyphrases

rheumatoid arthritis
disease activity
systemic lupus erythematosus
bone marrow
human health
drug induced
systemic sclerosis
replacement therapy