Targeted gene panel analysis of Japanese patients with maturity-onset diabetes of the young-like diabetes mellitus: Roles of inactivating variants in the ABCC8 and insulin resistance genes.
Tohru YorifujiYoh WatanabeKana KitayamaYuki YamadaShinji HiguchiJun MoriMasaru KatoToru TakahashiTokuko OkudaTakane AoyamaPublished in: Journal of diabetes investigation (2022)
Causative genomic variants could be identified in at least 46.2% of clinically suspected MODY patients. ABCC8-MODY with inactivating variants could represent a distinct category of MODY. Genes of insulin resistance should be included in the sequencing panel for MODY.
Keyphrases
- copy number
- insulin resistance
- genome wide
- type diabetes
- glycemic control
- genome wide identification
- end stage renal disease
- adipose tissue
- metabolic syndrome
- high fat diet
- ejection fraction
- newly diagnosed
- polycystic ovary syndrome
- dna methylation
- cardiovascular disease
- peritoneal dialysis
- prognostic factors
- pulmonary embolism
- skeletal muscle
- bioinformatics analysis
- genome wide analysis
- single cell
- transcription factor
- gene expression
- drug delivery
- weight loss